Immune effects of corticosteroids in sepsis

2 Aug 2018

Immune effects of corticosteroids in sepsis.

In sepsis, there is sufficient evidence from animals and humans studies to support that glucocorticoids modulate innate immunity to promote the resolution of inflammation and organs failure.

Much less is known about the immune effects of mineralocorticoids though increasing evidence from laboratory investigations suggested that they might favorably impact the outcome from sepsis. So far, survival benefits in adults with septic shock have been shown only for the combination of hydrocortisone plus fludrocortisone and not from the administration of hydrocortisone alone.
by Heming et al. (2018)

Heming NM, Sivanandamoorthy SM, Meng PM, Bounab RM, Annane DM. Immune effects of corticosteroids in sepsis. Frontiers in Immunology. July 2018;9:1736.

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