COVID-19 severity and Inflammation - The New Insight

         The COVID-19 disease progression which is not different from sepsis model. A recent publication From the journal Clinical Chemistry and Laboratory Medicine (CCLM) showed that 70-90% patients had hypoinflammation instead of full blown hyperinflammation which is only 10-30% in stage 3-5. A full cytokine storm manifestation of COVID-19 sepsis is uncommon, but it is more like a cytokine "breeze".


Adapted from Cytokine “storm”, cytokine “breeze”, or both in COVID-19?
Lippi, Giuseppe and Plebani, Mario. "Cytokine “storm”, cytokine “breeze”, or both in COVID-19?" Clinical Chemistry and Laboratory Medicine (CCLM), vol. 59, no. 4, 2021, pp. 637-639.

        Based on this study finding, we, Malaysia Sepsis Alliance proposes a model of COVID-19 according to this finding. 

        According to this new insight, high dose steroid administration for COVID-19 patients shall be highly selected and shall not recommended to majority of COVID-19 patients who more likely to be hypoinflammatory hypoxia ('Silent Hypoxia')   (Hui-chin et al 2021)


         For further inquiries, please do email is at



No comments:

Post a Comment